University of Vienna
Research network CMM
Dept of Microbiology and Ecosystem Science
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Effective job submission
Prediction of secreted proteins and protein secretion systems
Main input for your job
Your e-mail address:
Will only be used for job notification and is not stored on the server
One or multiple protein sequences in FASTA format:
FASTA formatted protein sequences
Upload a FASTA formatted protein sequence file
: predicts Type III secreted proteins based on their signal peptide
Specify the minimal score of a secreted protein (allowed range 0.0 ... 1.0; see score plot in
2.0.1 (Sep 2015)
1.0.1 (Aug 2009)
Select the version of the
(beta): predicts Type IV secreted proteins based on amino acid composition in C-termini
Specify the minimal score (allowed range 0.0 ... 1.0; higher score, higher selectivity; default: 0.5).
: predicts Type III secreted proteins based on their secretion chaperon binding site
: predicts secreted proteins based on eukaryotic-like domains
Select the minimal Z-score of a protein domain enrichment in pathogenic bacteria (or your proteins in complete genome mode).
: predicts subcellular localization of secreted proteins in the host cell
Select the appropriate model for your host organism.
Genome mode: for protein sequences from (nearly) complete genomes
Select if your proteins represent a genome. This will enable Z-score refinement in
and allows the activation of
to estimate genome completeness
Minimal % genome completeness
is enabled, this threshold is used to decide whether a genome is complete or not. The recommended value for a reasonable application of
Optional: COG/NOG assignment file
: upload a file listing all
COGs/NOGs that are present in your genome (one COG/NOG accession per line; only NOGs on root level - no bactNOGs, gproNOGs etc.). As second column, delimited by tab, the protain name can be provided (optional).
Predicts Type III, IV, VI secretion systems for protein sequences from (nearly) complete genomes. If no COG/NOG assignment file is given, orthologous groups will be predicted by using
EffectiveELD 5.1: Eukaryotic-like domain prediction upgraded to Pfam 29
New release 5.0 of Eukaryotic-like domains finished
New EffectiveT3 model
EffectiveDB-updates and novel features for a better annotation of bacterial secreted proteins and Type III, IV, VI secretion systems.
Prediction of microbial phenotypes based on comparative genomics.
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